EFFECTS OF TRAMADOL ADMINISTRATION ON SOME BIOCHEMICAL PARAMETERS IN WISTER ALBINO RATS UNDER NON-INDUCTION OF PAIN
Keywords:
neurotransmitters; glutamine dehydrogenase; bilirubin; uric acid; urea; creatinineAbstract
This study investigates the effect of tramadol under non-induction of pain on some biochemical parameters in albino rats. A total of 24 albino rats were randomly divided into four groups of 6 members each. Group 1 received pellet and was allowed free access to water. This was the control. Groups 2, 3 and 4 received 50, 100 and 200 mg/Kg body weight of tramadol respectively. All the administrations were via oral intubation and were done once daily for 30 days. Neurotransmitters, glutamine dehydrogenase, glutaminase, and oxidative stress markers were determined in the brain homogenate using standard methods. Liver function markers, kidney function parameters and pancreatic markers were equally determined in the serum using standard methods. The results showed that levels of serotonin, dopamine, reduced glutathione, albumin and activities of catalase, super oxide dismutase,glutathione transferase, glutathione peroxidase, glutaminase and lipase were significantly (p<0.05) lowered in rats administered tramadol only in dose dependent manner when compared with the control. The results also revealed that administration of different doses of tramadol caused significant (p<0.05) increase in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, α-amylase, glutamine dehydrogenase and levels of total bilirubin, uric acid, urea, creatinine and malondialdehyde in dose dependent manner when compared with control. These results generally revealed that intake of tramadol under non-induction of pain caused significant alterations of some biochemical markers, which could lead to health consequences.
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